diff -r 2a18f6b85da2 Lib/unittest/main.py
--- a/Lib/unittest/main.py	Sun Apr 12 18:47:56 2015 -0400
+++ b/Lib/unittest/main.py	Mon Apr 13 13:48:17 2015 -0400
@@ -224,6 +224,15 @@
                 self._initArgParsers()
             self._discovery_parser.parse_args(argv, self)
 
+            # Issue 22812, strip quotes from quoted args on windows
+            # If the arg gets here with quotes on a non-windows system,
+            # then we should respect the caller's command line foo
+            if sys.platform[:3] == 'win':
+                QUOTE_CHARS = '\'"'
+                if self.pattern[0] in QUOTE_CHARS and \
+                   self.pattern[0]==self.pattern[-1]:
+                    self.pattern = self.pattern[1:-1]
+
         loader = self.testLoader if Loader is None else Loader()
         self.test = loader.discover(self.start, self.pattern, self.top)
 
diff -r 2a18f6b85da2 Lib/unittest/test/test_discovery.py
--- a/Lib/unittest/test/test_discovery.py	Sun Apr 12 18:47:56 2015 -0400
+++ b/Lib/unittest/test/test_discovery.py	Mon Apr 13 13:48:17 2015 -0400
@@ -9,6 +9,7 @@
 
 import unittest
 import unittest.test
+import unittest.mock
 
 
 class TestableTestProgram(unittest.TestProgram):
@@ -668,6 +669,25 @@
         self.assertTrue(program.failfast)
         self.assertTrue(program.catchbreak)
 
+        # Issue 22812, strip leading/trailing quotes (non-windows)
+        Loader.args = []
+        program = TestableTestProgram()
+        program._do_discovery(['-p', "'test*.py'"], Loader=Loader)
+        self.assertEqual(program.test, 'tests')
+        self.assertEqual(Loader.args, [('.', "'test*.py'", None)])
+        self.assertFalse(program.failfast)
+        self.assertFalse(program.catchbreak)
+
+        # Issue 22812, strip leading/trailing quotes (non-windows)
+        Loader.args = []
+        program = TestableTestProgram()
+        with unittest.mock.patch('sys.platform',new="win32"):
+            program._do_discovery(['-p', "'test*.py'"], Loader=Loader)
+        self.assertEqual(program.test, 'tests')
+        self.assertEqual(Loader.args, [('.', 'test*.py', None)])
+        self.assertFalse(program.failfast)
+        self.assertFalse(program.catchbreak)
+
     def setup_module_clash(self):
         class Module(object):
             __file__ = 'bar/foo.py'