diff --git a/Objects/listobject.c b/Objects/listobject.c
--- a/Objects/listobject.c
+++ b/Objects/listobject.c
@@ -199,7 +199,7 @@
         PyErr_BadInternalCall();
         return NULL;
     }
-    if (i < 0 || i >= Py_SIZE(op)) {
+    if ((size_t)i >= (size_t)(Py_SIZE(op))) {
         if (indexerr == NULL) {
             indexerr = PyUnicode_FromString(
                 "list index out of range");
@@ -223,7 +223,7 @@
         PyErr_BadInternalCall();
         return -1;
     }
-    if (i < 0 || i >= Py_SIZE(op)) {
+    if ((size_t)i >= (size_t)(Py_SIZE(op))) {
         Py_XDECREF(newitem);
         PyErr_SetString(PyExc_IndexError,
                         "list assignment index out of range");
@@ -414,7 +414,7 @@
 static PyObject *
 list_item(PyListObject *a, Py_ssize_t i)
 {
-    if (i < 0 || i >= Py_SIZE(a)) {
+    if ((size_t)i >= (size_t)(Py_SIZE(a))) {
         if (indexerr == NULL) {
             indexerr = PyUnicode_FromString(
                 "list index out of range");
@@ -731,7 +731,7 @@
 list_ass_item(PyListObject *a, Py_ssize_t i, PyObject *v)
 {
     PyObject *old_value;
-    if (i < 0 || i >= Py_SIZE(a)) {
+    if ((size_t)i >= (size_t)(Py_SIZE(a))) {
         PyErr_SetString(PyExc_IndexError,
                         "list assignment index out of range");
         return -1;
@@ -925,7 +925,7 @@
     }
     if (i < 0)
         i += Py_SIZE(self);
-    if (i < 0 || i >= Py_SIZE(self)) {
+    if ((size_t)i >= (size_t)(Py_SIZE(self))) {
         PyErr_SetString(PyExc_IndexError, "pop index out of range");
         return NULL;
     }