diff --git a/Lib/test/test_warnings.py b/Lib/test/test_warnings.py
--- a/Lib/test/test_warnings.py
+++ b/Lib/test/test_warnings.py
@@ -5,7 +5,7 @@
 import sys
 import unittest
 from test import support
-from test.script_helper import assert_python_ok
+from test.script_helper import assert_python_ok, assert_python_failure
 
 from test import warning_tests
 
@@ -862,6 +862,32 @@
         # of the script
         self.assertEqual(err, b'__main__:7: UserWarning: test')
 
+    def test_issue22898(self):
+        # Should not crash when interp->sysdict is NULL at the end of Python
+        # finalization.
+        code = """if 1:
+            import sys, traceback
+
+            class MyException(Exception):
+                def __init__(self, *args):
+                    1/0
+
+            def gen():
+                f = open('%s')
+                yield
+
+            g = gen()
+            next(g)
+            recursionlimit = sys.getrecursionlimit()
+            sys.setrecursionlimit(len(traceback.extract_stack()))
+            try:
+                g.throw(MyException)
+            finally:
+                sys.setrecursionlimit(recursionlimit)
+        """ % __file__
+        rc, out, err = assert_python_failure("-c", code)
+        # Check that the program does not fail with SIGSEV or SIGABRT.
+        self.assertEqual(rc, 1)
 
 def setUpModule():
     py_warnings.onceregistry.clear()
diff --git a/Python/_warnings.c b/Python/_warnings.c
--- a/Python/_warnings.c
+++ b/Python/_warnings.c
@@ -518,10 +518,19 @@
         *lineno = PyFrame_GetLineNumber(f);
     }
 
+    /* During Python finalization, warnings may be emited after
+     * interp->sysdict is cleared: set module to None to ignore the warning.
+     * See issue #22898. */
+    if (globals == NULL) {
+        *module = Py_None;
+        Py_INCREF(*module);
+        *registry = NULL;
+        return 0;
+    }
+
     *module = NULL;
 
     /* Setup registry. */
-    assert(globals != NULL);
     assert(PyDict_Check(globals));
     *registry = PyDict_GetItemString(globals, "__warningregistry__");
     if (*registry == NULL) {
@@ -665,7 +674,7 @@
     res = warn_explicit(category, message, filename, lineno, module, registry,
                         NULL);
     Py_DECREF(filename);
-    Py_DECREF(registry);
+    Py_XDECREF(registry);
     Py_DECREF(module);
     return res;
 }