diff -r d244e1770f1b Lib/distutils/tests/test_sysconfig.py
--- a/Lib/distutils/tests/test_sysconfig.py	Fri Nov 14 11:45:47 2014 -0800
+++ b/Lib/distutils/tests/test_sysconfig.py	Wed Nov 19 15:25:03 2014 -0800
@@ -127,8 +127,15 @@
 
     def test_sysconfig_module(self):
         import sysconfig as global_sysconfig
-        self.assertEqual(global_sysconfig.get_config_var('CFLAGS'),
-                         sysconfig.get_config_var('CFLAGS'))
+        # Strip out the -fprofile* flags from a 'make profile-opt' build
+        # as those will differ in global_sysconfig's build time generated
+        # _sysconfigdata.py vs what distutils parses out of the Makefile.
+        # See https://bugs.python.org/issue22904.
+        global_cflags = [
+            flag for flag in global_sysconfig.get_config_var('CFLAGS').split()
+            if not flag.startswith('-fprofile')]
+        distutils_cflags = sysconfig.get_config_var('CFLAGS').split()
+        self.assertEqual(global_cflags, distutils_cflags)
         self.assertEqual(global_sysconfig.get_config_var('LDFLAGS'),
                          sysconfig.get_config_var('LDFLAGS'))