diff -r 8676e436c0f0 Lib/sqlite3/dbapi2.py
--- a/Lib/sqlite3/dbapi2.py	Wed May 21 17:12:21 2014 +0300
+++ b/Lib/sqlite3/dbapi2.py	Mon May 26 23:56:40 2014 +0300
@@ -22,6 +22,7 @@
 
 import datetime
 import time
+from collections.abc import Sequence
 
 from _sqlite3 import *
 
@@ -50,6 +51,7 @@
 sqlite_version_info = tuple([int(x) for x in sqlite_version.split(".")])
 
 Binary = memoryview
+Sequence.register(Row)
 
 def register_adapters_and_converters():
     def adapt_date(val):
diff -r 8676e436c0f0 Lib/sqlite3/test/factory.py
--- a/Lib/sqlite3/test/factory.py	Wed May 21 17:12:21 2014 +0300
+++ b/Lib/sqlite3/test/factory.py	Mon May 26 23:56:40 2014 +0300
@@ -23,6 +23,7 @@
 
 import unittest
 import sqlite3 as sqlite
+from collections.abc import Sequence
 
 class MyConnection(sqlite.Connection):
     def __init__(self, *args, **kwargs):
@@ -142,6 +143,21 @@
         self.assertNotEqual(row_1, row_3)
         self.assertNotEqual(hash(row_1), hash(row_3))
 
+    def CheckSqliteRowAsSequence(self):
+        """ Checks if the row object can act like a sequence """
+        self.con.row_factory = sqlite.Row
+        row = self.con.execute("select 1 as a, 2 as b").fetchone()
+
+        as_tuple = tuple(row)
+        self.assertEqual(list(reversed(row)), list(reversed(as_tuple)))
+        self.assertEqual(row[-1], 2)
+        self.assertEqual(row[-2], 1)
+        with self.assertRaises(IndexError):
+            row[-3]
+        with self.assertRaises(OverflowError):
+            row[2 ** 1000]
+        self.assertIsInstance(row, Sequence)
+
     def tearDown(self):
         self.con.close()
 
diff -r 8676e436c0f0 Modules/_sqlite/row.c
--- a/Modules/_sqlite/row.c	Wed May 21 17:12:21 2014 +0300
+++ b/Modules/_sqlite/row.c	Mon May 26 23:56:40 2014 +0300
@@ -63,9 +63,17 @@
     return 0;
 }
 
+PyObject* pysqlite_row_item(pysqlite_Row* self, Py_ssize_t idx)
+{
+   PyObject* item = PyTuple_GetItem(self->data, idx);
+   Py_XINCREF(item);
+   return item;
+}
+
 PyObject* pysqlite_row_subscript(pysqlite_Row* self, PyObject* idx)
 {
     long _idx;
+    int long_overflow;
     char* key;
     Py_ssize_t nitems, i;
     char* compare_key;
@@ -75,8 +83,15 @@
 
     PyObject* item;
 
-    if (PyLong_Check(idx)) {
-        _idx = PyLong_AsLong(idx);
+    if (PyLong_Check(idx)) {        
+        _idx = PyLong_AsLongAndOverflow(idx, &long_overflow);
+        if (long_overflow) {
+           PyErr_SetString(PyExc_OverflowError,
+                           "Row index doesn't fit into a long.");
+           return NULL;
+        }
+        if (_idx < 0)
+           _idx += PyTuple_GET_SIZE(self->data);
         item = PyTuple_GetItem(self->data, _idx);
         Py_XINCREF(item);
         return item;
@@ -198,6 +213,14 @@
     /* mp_ass_subscript */ (objobjargproc)0,
 };
 
+static PySequenceMethods pysqlite_row_as_sequence = {
+   /* sq_length */         (lenfunc)pysqlite_row_length,
+   /* sq_concat */         0,                                
+   /* sq_repeat */         0,                                
+   /* sq_item */           (ssizeargfunc)pysqlite_row_item,        
+};
+
+
 static PyMethodDef pysqlite_row_methods[] = {
     {"keys", (PyCFunction)pysqlite_row_keys, METH_NOARGS,
         PyDoc_STR("Returns the keys of the row.")},
@@ -251,5 +274,6 @@
 {
     pysqlite_RowType.tp_new = PyType_GenericNew;
     pysqlite_RowType.tp_as_mapping = &pysqlite_row_as_mapping;
+    pysqlite_RowType.tp_as_sequence = &pysqlite_row_as_sequence;
     return PyType_Ready(&pysqlite_RowType);
 }