diff -r ef5e61ac27ad Makefile.pre.in
--- a/Makefile.pre.in	Wed Jan 23 09:30:34 2013 +0000
+++ b/Makefile.pre.in	Fri Jan 25 12:58:36 2013 +0100
@@ -86,6 +86,9 @@
 # Machine-dependent subdirectories
 MACHDEP=	@MACHDEP@
 
+# Multiarch directory (may be empty)
+MULTIARCH=	@MULTIARCH@
+
 # Install prefix for architecture-independent files
 prefix=		@prefix@
 
@@ -980,6 +983,7 @@
 	export PYTHONPATH; PYTHONPATH="`pwd`/Lib"; \
 	export DYLD_FRAMEWORK_PATH; DYLD_FRAMEWORK_PATH="`pwd`"; \
 	export EXE; EXE="$(BUILDEXE)"; \
+	if [ -n "$(MULTIARCH)" ]; then export MULTIARCH; MULTIARCH=$(MULTIARCH); fi; \
 	cd $(srcdir)/Lib/$(PLATDIR); $(RUNSHARED) ./regen
 
 python-config: $(srcdir)/Misc/python-config.in
diff -r ef5e61ac27ad Tools/scripts/h2py.py
--- a/Tools/scripts/h2py.py	Wed Jan 23 09:30:34 2013 +0000
+++ b/Tools/scripts/h2py.py	Fri Jan 25 12:58:36 2013 +0100
@@ -58,6 +58,12 @@
                 raise KeyError
         except KeyError:
             searchdirs=['/usr/include']
+            try:
+                searchdirs.insert(0, os.path.join('/usr/include',
+                                                  os.environ['MULTIARCH']))
+            except KeyError:
+                pass
+
 
 def main():
     global filedict
diff -r ef5e61ac27ad configure.ac
--- a/configure.ac	Wed Jan 23 09:30:34 2013 +0000
+++ b/configure.ac	Fri Jan 25 12:58:36 2013 +0100
@@ -603,6 +603,9 @@
   ])
 fi
 
+MULTIARCH=$($CC --print-multiarch 2>/dev/null)
+AC_SUBST(MULTIARCH)
+
 
 # checks for UNIX variants that set C preprocessor variables
 AC_USE_SYSTEM_EXTENSIONS