diff --git a/Objects/fileobject.c b/Objects/fileobject.c
--- a/Objects/fileobject.c
+++ b/Objects/fileobject.c
@@ -1083,8 +1083,11 @@ file_read(PyFileObject *f, PyObject *arg
                   buffersize - bytesread, f->f_fp, (PyObject *)f);
         FILE_END_ALLOW_THREADS(f)
         if (chunksize == 0) {
-            if (!ferror(f->f_fp))
+            if (!ferror(f->f_fp)) {
+                /* clear the EOF indicator */
+                clearerr(f->f_fp);
                 break;
+            }
             clearerr(f->f_fp);
             /* When in non-blocking mode, data shouldn't
              * be discarded if a blocking signal was