diff --git a/Lib/unittest/test/test_case.py b/Lib/unittest/test/test_case.py
--- a/Lib/unittest/test/test_case.py
+++ b/Lib/unittest/test/test_case.py
@@ -595,6 +595,19 @@ class Test_TestCase(unittest.TestCase, T
         self.assertTupleEqual((), ())
         self.assertSequenceEqual([], ())
 
+        a = ['str']
+        b = [b'bytes']
+        with warnings.catch_warnings():
+            warnings.simplefilter("error", BytesWarning)
+            self.assertRaises(unittest.TestCase.failureException,
+                              self.assertEqual, 'str', b'bytes')
+            self.assertRaises(unittest.TestCase.failureException,
+                              self.assertListEqual, a, b)
+            self.assertRaises(unittest.TestCase.failureException,
+                              self.assertListEqual, tuple(a), tuple(b))
+            self.assertRaises(unittest.TestCase.failureException,
+                              self.assertSequenceEqual, a, tuple(b))
+
         a = [0, 'a', []]
         b = []
         self.assertRaises(unittest.TestCase.failureException,