Index: Lib/test/test_array.py
===================================================================
--- Lib/test/test_array.py	(revision 75254)
+++ Lib/test/test_array.py	(working copy)
@@ -188,6 +188,30 @@
                 f.close()
             test_support.unlink(test_support.TESTFN)
 
+    def test_fromfile_ioerror(self):
+        # Issue #5395: Check if fromfile raises a proper IOError
+        # instead of EOFError.
+        import os
+        a = array.array(self.typecode, self.example)
+        f = open(test_support.TESTFN, 'wb')
+        try:
+            f.write(a)
+            f.close()
+            b = array.array(self.typecode)
+            f = open(test_support.TESTFN, 'rb')
+            # Close only the file descriptor, so f seems still open.
+            os.close(f.fileno())
+            self.assertRaises(IOError, b.fromfile, f, len(a))
+        finally:
+            if not f.closed:
+                try:
+                    f.close()
+                except IOError:
+                    # In case the file descriptor has already been closed
+                    # f.close() fails.
+                    pass
+            test_support.unlink(test_support.TESTFN)
+
     def test_filewrite(self):
         a = array.array(self.typecode, 2*self.example)
         f = open(test_support.TESTFN, 'wb')
Index: Modules/arraymodule.c
===================================================================
--- Modules/arraymodule.c	(revision 75254)
+++ Modules/arraymodule.c	(working copy)
@@ -1228,8 +1228,14 @@
 			PyMem_RESIZE(item, char, Py_SIZE(self)*itemsize);
 			self->ob_item = item;
 			self->allocated = Py_SIZE(self);
-			PyErr_SetString(PyExc_EOFError,
-				         "not enough items in file");
+			if (ferror(fp)) {
+				PyErr_SetFromErrno(PyExc_IOError);
+				clearerr(fp);
+			}
+			else {
+				PyErr_SetString(PyExc_EOFError,
+					         "not enough items in file");
+			}
 			return NULL;
 		}
 	}