Index: Lib/test/test_array.py
===================================================================
--- Lib/test/test_array.py	(revision 75227)
+++ Lib/test/test_array.py	(working copy)
@@ -188,6 +188,27 @@
                 f.close()
             test_support.unlink(test_support.TESTFN)
 
+    def test_fromfile_ioerror(self):
+        # Issue #5395: Check if fromfile raises a proper IOError
+        # instead of EOFError.
+        try:
+            import os
+        except ImportError:
+            return
+        a = array.array(self.typecode, self.example)
+        f = open(test_support.TESTFN, 'wb')
+        try:
+            f.write(a)
+            f.close()
+            b = array.array(self.typecode)
+            f = open(test_support.TESTFN, 'rb')
+            os.close(f.fileno())
+            self.assertRaises(IOError, b.fromfile, f, len(a))
+        finally:
+            if not f.closed:
+                test_support.expect_exception(IOError, f.close)
+            test_support.unlink(test_support.TESTFN)
+
     def test_filewrite(self):
         a = array.array(self.typecode, 2*self.example)
         f = open(test_support.TESTFN, 'wb')
Index: Lib/test/test_support.py
===================================================================
--- Lib/test/test_support.py	(revision 75227)
+++ Lib/test/test_support.py	(working copy)
@@ -458,6 +458,16 @@
         file.close()
         unlink(TESTFN)
 
+def expect_exception(exception, function, *args):
+    """
+    Call a function and catch the expected exception. Don't handly any other
+    Exceptions.
+    """
+    try:
+        function(*args)
+    except exception:
+        pass
+
 def check_syntax_error(testcase, statement):
     testcase.assertRaises(SyntaxError, compile, statement,
                           '<test string>', 'exec')
Index: Modules/arraymodule.c
===================================================================
--- Modules/arraymodule.c	(revision 75227)
+++ Modules/arraymodule.c	(working copy)
@@ -1228,8 +1228,14 @@
 			PyMem_RESIZE(item, char, Py_SIZE(self)*itemsize);
 			self->ob_item = item;
 			self->allocated = Py_SIZE(self);
-			PyErr_SetString(PyExc_EOFError,
-				         "not enough items in file");
+			if (ferror(fp)) {
+				PyErr_SetFromErrno(PyExc_IOError);
+				clearerr(fp);
+			}
+			else {
+				PyErr_SetString(PyExc_EOFError,
+					         "not enough items in file");
+			}
 			return NULL;
 		}
 	}