Index: Lib/test/test_array.py
===================================================================
--- Lib/test/test_array.py	(revision 75038)
+++ Lib/test/test_array.py	(working copy)
@@ -8,6 +8,7 @@
 from weakref import proxy
 import array, cStringIO
 from cPickle import loads, dumps, HIGHEST_PROTOCOL
+import os
 
 class ArraySubclass(array.array):
     pass
@@ -183,6 +184,16 @@
             self.assertEqual(a, b)
             self.assertRaises(EOFError, b.fromfile, f, 1)
             f.close()
+
+            # Issue #5395: Check if fromfile raises a propper IOError
+            # instead of EOFError.
+            f = open(test_support.TESTFN, 'rb')
+            os.close(f.fileno())
+            self.assertRaises(IOError, b.fromfile, f, len(a))
+            try:
+                f.close()
+            except IOError:
+                pass
         finally:
             if not f.closed:
                 f.close()
Index: Modules/arraymodule.c
===================================================================
--- Modules/arraymodule.c	(revision 75038)
+++ Modules/arraymodule.c	(working copy)
@@ -1228,8 +1228,14 @@
 			PyMem_RESIZE(item, char, Py_SIZE(self)*itemsize);
 			self->ob_item = item;
 			self->allocated = Py_SIZE(self);
-			PyErr_SetString(PyExc_EOFError,
-				         "not enough items in file");
+			if (ferror(fp)) {
+				PyErr_SetFromErrno(PyExc_IOError);
+				clearerr(fp);
+			}
+			else {
+				PyErr_SetString(PyExc_EOFError,
+					         "not enough items in file");
+			}
 			return NULL;
 		}
 	}