I permanently use gc.disable() but CPython create object with GC_Head.
it's use big memory.
I suggest add define to a few file that remove use GC_Head and allocate extra memory.

Could you please try to elaborate a little bit the issue?

> I permanently use gc.disable() but CPython create object with GC_Head.
it's use big memory.

You propose to remove GC_Head for everywhere? Or do you want a configure option?

What do you mean by "big memory"? Do you have an estimation of the "overhead" on an application?

I'm going to do this under define, as an option. In my application it consumes several mBs + it's some performance for handling  this structure.

This seems like something that would require a PEP, or at least a discussion on python-ideas.

I only saw yuriy_levchenko's request in 2016, it doesn't sound like a popular request. Disabling completely the GC is an invasive change, the GC is part of the Python semantics. I agree with Irit, this idea should be discussed on python-ideas first. I close this issue.

Note: I moved the PyGC_Head structure to the internal C API in Python 3.9, see bpo-40241.