Currently, the new "with" statement does not support multiple handlers. 
For example, to open two files for input/output you would have to do:

with open("filein") as input:
    with open("fileout") as output:
        #Do stuff
        pass

This adds unnecessary complexity, and would be unwieldy with multiple 
code blocks. Would something like the following be feasible?

with open("filein") as input, open("fileout") as output:
    # Do stuff
    pass

This syntax is fully backwards-compatible, so there shouldn't be any 
problem there.

What this syntax does is similar to the nested context manager in case 
12 of PEP343, but with cleaner syntax.

I don't think the added syntactic complexity is worth the relatively
rare use case, especially since there's already an implementation of
nested() in the contextlib library.