diff -r 2b7b203e3909 Lib/test/test_typing.py
--- a/Lib/test/test_typing.py	Wed Jan 11 20:18:03 2017 +0200
+++ b/Lib/test/test_typing.py	Wed Jan 11 14:55:39 2017 -0800
@@ -217,6 +217,9 @@
         self.assertNotEqual(u2, Any)
         self.assertNotEqual(u3, Any)
 
+    def test_union_compare_other(self):
+        self.assertNotEqual(Union, object)
+
     def test_union_object(self):
         u = Union[object]
         self.assertEqual(u, object)
diff -r 2b7b203e3909 Lib/typing.py
--- a/Lib/typing.py	Wed Jan 11 20:18:03 2017 +0200
+++ b/Lib/typing.py	Wed Jan 11 14:55:39 2017 -0800
@@ -757,7 +757,7 @@
 
     def __eq__(self, other):
         if not isinstance(other, _Union):
-            return self._subs_tree() == other
+            return self._subs_tree() is not self and self._subs_tree() == other
         return self.__tree_hash__ == other.__tree_hash__
 
     def __hash__(self):