diff -r d23ac799fe83 Lib/pdb.py
--- a/Lib/pdb.py	Sun Oct 02 11:43:25 2016 +0200
+++ b/Lib/pdb.py	Sun Oct 02 18:02:45 2016 +0200
@@ -135,6 +135,8 @@
 
 class Pdb(bdb.Bdb, cmd.Cmd):
 
+    _previous_sigint_handler = None
+
     def __init__(self, completekey='tab', stdin=None, stdout=None, skip=None,
                  nosigint=False, readrc=True):
         bdb.Bdb.__init__(self, skip=skip)
@@ -189,8 +191,6 @@
         self.message("\nProgram interrupted. (Use 'cont' to resume).")
         self.set_step()
         self.set_trace(frame)
-        # restore previous signal handler
-        signal.signal(signal.SIGINT, self._previous_sigint_handler)
 
     def reset(self):
         bdb.Bdb.reset(self)
@@ -339,6 +339,10 @@
                                  (expr, newvalue, oldvalue))
 
     def interaction(self, frame, traceback):
+        # Restore the previous signal handler at the Pdb prompt.
+        if Pdb._previous_sigint_handler:
+            signal.signal(signal.SIGINT, Pdb._previous_sigint_handler)
+            Pdb._previous_sigint_handler = None
         if self.setup(frame, traceback):
             # no interaction desired at this time (happens if .pdbrc contains
             # a command like "continue")
@@ -1039,7 +1043,7 @@
         """
         if not self.nosigint:
             try:
-                self._previous_sigint_handler = \
+                Pdb._previous_sigint_handler = \
                     signal.signal(signal.SIGINT, self.sigint_handler)
             except ValueError:
                 # ValueError happens when do_continue() is invoked from
diff -r d23ac799fe83 Lib/test/test_pdb.py
--- a/Lib/test/test_pdb.py	Sun Oct 02 11:43:25 2016 +0200
+++ b/Lib/test/test_pdb.py	Sun Oct 02 18:02:45 2016 +0200
@@ -911,6 +911,29 @@
     (Pdb) continue
     """
 
+def test_pdb_issue_20766():
+    """Test for reference leaks when the SIGINT handler is set.
+
+    >>> def test_function():
+    ...     i = 1
+    ...     while i <= 2:
+    ...         sess = pdb.Pdb()
+    ...         sess.set_trace(sys._getframe())
+    ...         print('pdb %d: %s' % (i, sess._previous_sigint_handler))
+    ...         i += 1
+
+    >>> with PdbTestInput(['continue',
+    ...                    'continue']):
+    ...     test_function()
+    > <doctest test.test_pdb.test_pdb_issue_20766[0]>(6)test_function()
+    -> print('pdb %d: %s' % (i, sess._previous_sigint_handler))
+    (Pdb) continue
+    pdb 1: <built-in function default_int_handler>
+    > <doctest test.test_pdb.test_pdb_issue_20766[0]>(5)test_function()
+    -> sess.set_trace(sys._getframe())
+    (Pdb) continue
+    pdb 2: <built-in function default_int_handler>
+    """
 
 class PdbTestCase(unittest.TestCase):