diff -r 20bd4c23cfe4 Doc/library/inspect.rst
--- a/Doc/library/inspect.rst	Tue May 31 20:17:58 2016 -0400
+++ b/Doc/library/inspect.rst	Wed Jun 01 12:05:07 2016 -0700
@@ -591,11 +591,13 @@
          >>> str(new_sig)
          "(a, b) -> 'new return anno'"
 
-   .. classmethod:: Signature.from_callable(obj, \*, follow_wrapped=True)
+   .. classmethod:: Signature.from_callable(obj, \*, follow_wrapped=True, skip_bound_arg=True)
 
        Return a :class:`Signature` (or its subclass) object for a given callable
        ``obj``.  Pass ``follow_wrapped=False`` to get a signature of ``obj``
-       without unwrapping its ``__wrapped__`` chain.
+       without unwrapping its ``__wrapped__`` chain.  Pass
+       ``skip_bound_arg=False`` to get a signature of ``obj`` that includes the
+       bound argument (i.e., ``obj.__self__``).
 
        This method simplifies subclassing of :class:`Signature`::
 
@@ -606,6 +608,8 @@
 
        .. versionadded:: 3.5
 
+       .. versionchanged:: 3.6
+          The *skip_bound_arg* argument was added.
 
 .. class:: Parameter(name, kind, \*, default=Parameter.empty, annotation=Parameter.empty)
 
diff -r 20bd4c23cfe4 Doc/whatsnew/3.6.rst
--- a/Doc/whatsnew/3.6.rst	Tue May 31 20:17:58 2016 -0400
+++ b/Doc/whatsnew/3.6.rst	Wed Jun 01 12:05:07 2016 -0700
@@ -281,6 +281,13 @@
 :issue:`23848`.)
 
 
+inspect
+--------
+
+The :meth:`~inspect.Signature.from_callable` method now supports the
+*skip_bound_arg* argument.  (Contributed by Ryan Petrello in :issue:`27172`.)
+
+
 os
 --
 
diff -r 20bd4c23cfe4 Lib/inspect.py
--- a/Lib/inspect.py	Tue May 31 20:17:58 2016 -0400
+++ b/Lib/inspect.py	Wed Jun 01 12:05:07 2016 -0700
@@ -2711,10 +2711,11 @@
         return _signature_from_builtin(cls, func)
 
     @classmethod
-    def from_callable(cls, obj, *, follow_wrapped=True):
+    def from_callable(cls, obj, *, follow_wrapped=True, skip_bound_arg=True):
         """Constructs Signature for the given callable object."""
         return _signature_from_callable(obj, sigcls=cls,
-                                        follow_wrapper_chains=follow_wrapped)
+                                        follow_wrapper_chains=follow_wrapped,
+                                        skip_bound_arg=skip_bound_arg)
 
     @property
     def parameters(self):
diff -r 20bd4c23cfe4 Lib/test/test_inspect.py
--- a/Lib/test/test_inspect.py	Tue May 31 20:17:58 2016 -0400
+++ b/Lib/test/test_inspect.py	Wed Jun 01 12:05:07 2016 -0700
@@ -2865,6 +2865,19 @@
         foo_sig = MySignature.from_callable(foo)
         self.assertTrue(isinstance(foo_sig, MySignature))
 
+    def test_signature_from_callable_python_obj_with_bound_arg(self):
+        class MyObj:
+            def foo(self, a, b, c):
+                pass
+        inst = MyObj()
+
+        foo_sig = inspect.Signature.from_callable(inst.foo)
+        self.assertEqual(list(foo_sig.parameters), ['a', 'b', 'c'])  
+
+        with_self = inspect.Signature.from_callable(inst.foo,
+                                                    skip_bound_arg=False)
+        self.assertEqual(list(with_self.parameters), ['self', 'a', 'b', 'c'])  
+
     @unittest.skipIf(MISSING_C_DOCSTRINGS,
                      "Signature information for builtins requires docstrings")
     def test_signature_from_callable_builtin_obj(self):