diff -r f6a89f6cadd0 Python/ceval.c
--- a/Python/ceval.c	Fri Feb 05 18:26:20 2016 -0500
+++ b/Python/ceval.c	Sat Feb 06 02:43:45 2016 +0100
@@ -1591,7 +1607,23 @@ PyEval_EvalFrameEx(PyFrameObject *f, int
         TARGET(BINARY_SUBSCR) {
             PyObject *sub = POP();
             PyObject *container = TOP();
-            PyObject *res = PyObject_GetItem(container, sub);
+            int slow_path = 1;
+            PyObject *res;
+
+            if (PyList_CheckExact(container) && PyLong_CheckExact(sub)) {
+                /* INLINE: list[int] */
+                Py_ssize_t i = PyLong_AsSsize_t(sub);
+                if (i < 0)
+                    i += PyList_GET_SIZE(container);
+                if (i >= 0 && i < PyList_GET_SIZE(container)) {
+                    res = PyList_GET_ITEM(container, i);
+                    Py_INCREF(res);
+                    slow_path = 0;
+                }
+            }
+
+            if (slow_path)
+                res = PyObject_GetItem(container, sub);
             Py_DECREF(container);
             Py_DECREF(sub);
             SET_TOP(res);