diff -r 001514146c21 Lib/test/test_itertools.py
--- a/Lib/test/test_itertools.py	Mon Dec 07 11:32:00 2015 +0200
+++ b/Lib/test/test_itertools.py	Mon Dec 07 15:18:08 2015 +0200
@@ -1448,6 +1448,16 @@ class TestExamples(unittest.TestCase):
         self.assertEqual(list(copy.deepcopy(it)), accumulated[1:])
         self.assertEqual(list(copy.copy(it)), accumulated[1:])
 
+    def test_accumulate_reducible_none(self):
+        # Issue #25718: total is None
+        it = accumulate([None, None, None], operator.is_)
+        self.assertEqual(next(it), None)
+        for proto in range(pickle.HIGHEST_PROTOCOL + 1):
+            it_copy = pickle.loads(pickle.dumps(it, proto))
+            self.assertEqual(list(it_copy), [True, False])
+        self.assertEqual(list(copy.deepcopy(it)), [True, False])
+        self.assertEqual(list(copy.copy(it)), [True, False])
+
     def test_chain(self):
         self.assertEqual(''.join(chain('ABC', 'DEF')), 'ABCDEF')
 
diff -r 001514146c21 Modules/itertoolsmodule.c
--- a/Modules/itertoolsmodule.c	Mon Dec 07 11:32:00 2015 +0200
+++ b/Modules/itertoolsmodule.c	Mon Dec 07 15:18:08 2015 +0200
@@ -3488,6 +3488,23 @@ accumulate_next(accumulateobject *lz)
 static PyObject *
 accumulate_reduce(accumulateobject *lz)
 {
+    if (lz->total == Py_None) {
+        PyObject *it;
+
+        if (PyType_Ready(&chain_type) < 0)
+            return NULL;
+        if (PyType_Ready(&islice_type) < 0)
+            return NULL;
+        it = PyObject_CallFunction((PyObject *)&chain_type, "(O)O",
+                                   lz->total, lz->it);
+        if (it == NULL)
+            return NULL;
+        it = PyObject_CallFunction((PyObject *)Py_TYPE(lz), "NO",
+                                   it, lz->binop?lz->binop:Py_None);
+        if (it == NULL)
+            return NULL;
+        return Py_BuildValue("O(NiO)", &islice_type, it, 1, Py_None);
+    }
     return Py_BuildValue("O(OO)O", Py_TYPE(lz),
                             lz->it, lz->binop?lz->binop:Py_None,
                             lz->total?lz->total:Py_None);