diff -r ed4ffd602f4e Python/fileutils.c
--- a/Python/fileutils.c	Sun Aug 24 18:08:22 2014 -0500
+++ b/Python/fileutils.c	Mon Aug 25 02:59:40 2014 +0200
@@ -625,10 +625,12 @@ set_inheritable(int fd, int inheritable,
 #ifdef MS_WINDOWS
     HANDLE handle;
     DWORD flags;
-#elif defined(HAVE_SYS_IOCTL_H) && defined(FIOCLEX) && defined(FIONCLEX)
+#else
+#if defined(HAVE_SYS_IOCTL_H) && defined(FIOCLEX) && defined(FIONCLEX)
+    static int ioctl_works = -1;
     int request;
     int err;
-#elif defined(HAVE_FCNTL_H)
+#endif
     int flags;
     int res;
 #endif
@@ -674,20 +676,38 @@ set_inheritable(int fd, int inheritable,
     }
     return 0;
 
-#elif defined(HAVE_SYS_IOCTL_H) && defined(FIOCLEX) && defined(FIONCLEX)
-    if (inheritable)
-        request = FIONCLEX;
-    else
-        request = FIOCLEX;
-    err = ioctl(fd, request, NULL);
-    if (err) {
-        if (raise)
-            PyErr_SetFromErrno(PyExc_OSError);
-        return -1;
+#else
+
+#if defined(HAVE_SYS_IOCTL_H) && defined(FIOCLEX) && defined(FIONCLEX)
+    if (ioctl_works != 0) {
+        /* fast-path: ioctl() only requires one syscall */
+        if (inheritable)
+            request = FIONCLEX;
+        else
+            request = FIOCLEX;
+        err = ioctl(fd, request, NULL);
+        if (!err) {
+            ioctl_works = 1;
+            return 0;
+        }
+
+        if (errno != ENOTTY) {
+            if (raise)
+                PyErr_SetFromErrno(PyExc_OSError);
+            return -1;
+        }
+        else {
+            /* Issue #22258: Here, ENOTTY means "Inappropriate ioctl for
+               device". The ioctl is declared but not supported by the kernel.
+               Remember that ioctl() doesn't work. It is the case on
+               Illumos-based OS for example. */
+            ioctl_works = 0;
+        }
+        /* fallback to fcntl() if ioctl() does not work */
     }
-    return 0;
+#endif
 
-#else
+    /* slow-path: fcntl() requires two syscalls */
     flags = fcntl(fd, F_GETFD);
     if (flags < 0) {
         if (raise)