diff -r 9b450b19aa11 Lib/test/test_struct.py
--- a/Lib/test/test_struct.py	Sat Jul 12 03:20:40 2014 +0200
+++ b/Lib/test/test_struct.py	Mon Jul 21 10:07:15 2014 +0200
@@ -487,6 +487,28 @@
             value, = struct.unpack('>I', data)
             self.assertEqual(value, 0x12345678)
 
+    def test_native_bool(self):
+        # See issue 22012 for more information
+        sz = struct.calcsize('@?')
+
+        buf = b'\x00'*(sz)
+        self.assertEqual(struct.unpack('@?', buf), (False,))
+
+        buf = b'\x00'*(sz)
+        if sys.byteorder == 'little':
+            buf = (buf + b'\x01')[1:]
+        else:
+            buf = (b'\x01' + buf)[1:]
+        self.assertEqual(struct.unpack('@?', buf), (True,))
+
+        buf = b'\x00'*(sz)
+        if sys.byteorder == 'little':
+            buf = (buf + b'\x02')[1:]
+        else:
+            buf = (b'\x02' + buf)[1:]
+        self.assertEqual(struct.unpack('@?', buf), (True,))
+
+
     def test_bool(self):
         class ExplodingBool(object):
             def __bool__(self):
diff -r 9b450b19aa11 Modules/_struct.c
--- a/Modules/_struct.c	Sat Jul 12 03:20:40 2014 +0200
+++ b/Modules/_struct.c	Mon Jul 21 10:07:15 2014 +0200
@@ -463,7 +463,40 @@
 static PyObject *
 nu_bool(const char *p, const formatdef *f)
 {
+    /*
+     * The documentation says that any non-zero value
+     * will be converted to True. The C standard says that
+     * _Bool values can only be 0 or 1, and some compilers
+     * (in particular clang) ignore anything but the least
+     * significant bit of the _Bool value.
+     *
+     * The size of _Bool might not be 1 either, hence we cannot
+     * use bu_bool here.
+     */
+#ifdef HAVE_C99_BOOL
+
+#if SIZEOF__BOOL == 1
+    unsigned char x;
+
+#elif SIZEOF__BOOL == SIZEOF_SHORT
+    unsigned short x;
+
+#elif SIZEOF__BOOL == SIZEOF_INT
+    unsigned int x;
+
+#elif SIZEOF__BOOL == SIZEOF_LONG
+    unsigned long x;
+
+#else
+
+# error "Don't know how to convert _Bool"
+#endif
+
+#else /* !HAVE_C99_BOOL */
     BOOL_TYPE x;
+
+#endif
+
     memcpy((char *)&x, p, sizeof x);
     return PyBool_FromLong(x != 0);
 }