diff -r cb9a3985df00 Lib/distutils/util.py
--- a/Lib/distutils/util.py	Thu May 08 17:43:25 2014 -0500
+++ b/Lib/distutils/util.py	Fri May 09 11:06:03 2014 +0200
@@ -102,6 +102,8 @@
         osname, release, machine = _osx_support.get_platform_osx(
                                         distutils.sysconfig.get_config_vars(),
                                         osname, release, machine)
+    elif osname[:9] == "dragonfly":
+        release = str.split(release, "-")[0]
 
     return "%s-%s-%s" % (osname, release, machine)
 
diff -r cb9a3985df00 Modules/nismodule.c
--- a/Modules/nismodule.c	Thu May 08 17:43:25 2014 -0500
+++ b/Modules/nismodule.c	Fri May 09 11:06:03 2014 +0200
@@ -89,7 +89,7 @@
     return map;
 }
 
-#if defined(__APPLE__) || defined(__OpenBSD__) || defined(__FreeBSD__)
+#if defined(__APPLE__) || defined(__OpenBSD__) || defined(__FreeBSD__) || defined(__DragonFly__)
 typedef int (*foreachfunc)(unsigned long, char *, int, char *, int, void *);
 #else
 typedef int (*foreachfunc)(int, char *, int, char *, int, char *);
diff -r cb9a3985df00 setup.py
--- a/setup.py	Thu May 08 17:43:25 2014 -0500
+++ b/setup.py	Fri May 09 11:06:03 2014 +0200
@@ -1507,6 +1529,14 @@
             macros = dict()
             libraries = []
 
+        elif host_platform.startswith('dragonfly'):
+            macros = dict(
+                HAVE_SEM_OPEN=0,
+                HAVE_SEM_TIMEDWAIT=0,
+                HAVE_FD_TRANSFER=1,
+                )
+            libraries = []
+
         else:                                   # Linux and other unices
             macros = dict()
             libraries = ['rt']