diff --git a/Tools/scripts/patchcheck.py b/Tools/scripts/patchcheck.py
--- a/Tools/scripts/patchcheck.py
+++ b/Tools/scripts/patchcheck.py
@@ -148,6 +148,18 @@ def regenerated_pyconfig_h_in(file_paths
     else:
         return "not needed"
 
+@status("Files with argument clinic comments changed", modal=True)
+def argument_clinic_files_modified(file_paths):
+    """Check if files containing clinic comments have been modified."""
+    for path in file_paths:
+        abspath = os.path.join(SRCDIR, path)
+        try:
+            with open(abspath, 'rb') as f:
+                lines = f.readlines()
+                return any([b"[clinic input]" in line for line in lines])
+        except Exception as err:
+            print('Cannot fix %s: %s' % (path, err))
+
 def main():
     file_paths = changed_files()
     python_files = [fn for fn in file_paths if fn.endswith('.py')]
@@ -171,6 +183,8 @@ def main():
     regenerated_configure(file_paths)
     # Regenerated pyconfig.h.in, if necessary.
     regenerated_pyconfig_h_in(file_paths)
+    # Sources files with argument clinic comments modified.
+    argument_clinic_files_modified(c_files)
 
     # Test suite run and passed.
     if python_files or c_files: