diff --git Lib/_abcoll.py Lib/_abcoll.py
index 326c1f9..58b6672 100644
--- Lib/_abcoll.py
+++ Lib/_abcoll.py
@@ -305,18 +305,24 @@ class MutableSet(Set):
         return self
 
     def __ixor__(self, it):
-        if not isinstance(it, Set):
-            it = self._from_iterable(it)
-        for value in it:
-            if value in self:
-                self.discard(value)
-            else:
-                self.add(value)
+        if it is self:
+            self.clear()
+        else:
+            if not isinstance(it, Set):
+                it = self._from_iterable(it)
+            for value in it:
+                if value in self:
+                    self.discard(value)
+                else:
+                    self.add(value)
         return self
 
     def __isub__(self, it):
-        for value in it:
-            self.discard(value)
+        if it is self:
+            self.clear()
+        else:
+            for value in it:
+                self.discard(value)
         return self
 
 MutableSet.register(set)
diff --git Lib/test/test_collections.py Lib/test/test_collections.py
index 4330583..bec6dc0 100644
--- Lib/test/test_collections.py
+++ Lib/test/test_collections.py
@@ -487,6 +487,21 @@ class TestCollectionABCs(ABCTestCase):
         s = MySet([5,43,2,1])
         self.assertEqual(s.pop(), 1)
 
+    def test_issue8750(self):
+        empty = WithSet()
+        full = WithSet(range(10))
+        s = WithSet(full)
+        s -= s
+        self.assertEqual(s, empty)
+        s = WithSet(full)
+        s ^= s
+        self.assertEqual(s, empty)
+        s = WithSet(full)
+        s &= s
+        self.assertEqual(s, full)
+        s |= s
+        self.assertEqual(s, full)
+
     def test_Mapping(self):
         for sample in [dict]:
             self.assertIsInstance(sample(), Mapping)