Index: Lib/test/test_ssl.py
===================================================================
--- Lib/test/test_ssl.py	(revision 81162)
+++ Lib/test/test_ssl.py	(working copy)
@@ -182,6 +182,8 @@
         finally:
             s.close()
 
+    @unittest.skipIf(sys.platform.startswith('openbsd'),
+                     "OpenBSD has issues in libpthread")
     @unittest.skipIf(os.name == "nt", "Can't use a socket as a file under Windows")
     def test_makefile_close(self):
         # Issue #5238: creating a file-like object with makefile() shouldn't
Index: Lib/test/test_socket.py
===================================================================
--- Lib/test/test_socket.py	(revision 81162)
+++ Lib/test/test_socket.py	(working copy)
@@ -1142,6 +1142,8 @@
         if not ok:
             self.fail("accept() returned success when we did not expect it")
 
+    @unittest.skipIf(sys.platform.startswith('openbsd'),
+                     "OpenBSD has issues in libpthread")
     def testInterruptedTimeout(self):
         # XXX I don't know how to do this test on MSWindows or any other
         # plaform that doesn't support signal.alarm() or os.kill(), though
Index: Lib/test/test_signal.py
===================================================================
--- Lib/test/test_signal.py	(revision 81162)
+++ Lib/test/test_signal.py	(working copy)
@@ -226,6 +226,8 @@
         after_time = time.time()
         self.assertTrue(after_time - mid_time < self.TIMEOUT_HALF)
 
+    @unittest.skipIf(sys.platform.startswith('openbsd'),
+                     "OpenBSD has issues in libpthread")
     def test_wakeup_fd_during(self):
         import select
 
@@ -318,6 +320,8 @@
                     raise
                 return True
 
+    @unittest.skipIf(sys.platform.startswith('openbsd'),
+                     "OpenBSD has issues in libpthread")
     def test_without_siginterrupt(self):
         """If a signal handler is installed and siginterrupt is not called
         at all, when that signal arrives, it interrupts a syscall that's in
@@ -329,6 +333,8 @@
         i = self.readpipe_interrupted()
         self.assertTrue(i)
 
+    @unittest.skipIf(sys.platform.startswith('openbsd'),
+                     "OpenBSD has issues in libpthread")
     def test_siginterrupt_on(self):
         """If a signal handler is installed and siginterrupt is called with
         a true value for the second argument, when that signal arrives, it
@@ -440,6 +446,8 @@
         # and the handler should have been called
         self.assertEquals(self.hndl_called, True)
 
+    @unittest.skipIf(sys.platform.startswith('openbsd'),
+                     "OpenBSD has issues in libpthread")
     # Issue 3864. Unknown if this affects earlier versions of freebsd also.
     @unittest.skipIf(sys.platform=='freebsd6',
         'itimer not reliable (does not mix well with threading) on freebsd6')
Index: Lib/test/test_subprocess.py
===================================================================
--- Lib/test/test_subprocess.py	(revision 81162)
+++ Lib/test/test_subprocess.py	(working copy)
@@ -666,6 +666,8 @@
                                  "{} attempts".format(method, args, count))
         return p
 
+    @unittest.skipIf(sys.platform.startswith('openbsd'),
+                     "OpenBSD has issues in libpthread")
     def test_send_signal(self):
         p = self._kill_process('send_signal', signal.SIGINT)
         _, stderr = p.communicate()